Everything You Need To Know About Using Bromelain For Inflammation

Bromelain is a powerful anti-inflammatory enzyme found in pineapples that can help with everything from pain management to improved digestion. We asked functional medicine expert, Dr. Josh Axe, to break down the benefits and uses of bromelain...

What most people don’t realize about pineapples is that they’re infinitely more useful to humans than just as a garnish for tropical drinks. Due to powerful enzymes that the pineapple contains —especially the protein-digesting enzyme called bromelain — this delicious fruit is also literally medicine!

What Is Bromelain?

Pineapple, a South American native and a cherished part of Hawaiian folk medicine, is one of the richest sources in the world of the enzyme bromelain. It is composed of several endopeptidases and compounds like phosphatase, glucosidase, peroxidase, cellulase, escharase and protease inhibitors. Usually “bromelain” sold in extract or supplement form refers to enzymes extracted from pineapple stems or cores, rather than from the fruit’s flesh.

Used widely as a natural remedy to treat everything from indigestion to allergies, pineapple is not only brimming with this enzyme, but also vitamin C, vitamin B1, potassium, manganese and phytonutrients. While pineapple has many benefits, the real secret to its healing powers is definitely bromelain.

What is bromelain used to treat? In the medical world, this fascinating compound has traditionally been used as a potent anti-inflammatory and anti-swelling agent. Research have also shown that it has fibrinolytic, antiedematous and antithrombotic properties, meaning it helps prevent blood clots, edema and swelling.

In the past, this enzyme was also used as a meat tenderizer, reason being it helps to soothe and relax tense, inflamed muscles and connective tissue. Additionally, recent studies have found evidence that this enzyme stops lung metastasis in its tracks, which suggests that bromelain can be used to treat a wide variety of diseases, potentially including cancer.

A look at the scientific literature, which includes 1,600-plus articles evaluating the medicinal benefits of bromelain, shows that it has been used to treat a wide range of health problems, including: Connective tissue injuries, such as ACL tears, sprained ankles, tendonitis, allergies, arthritis, joint pain and osteoarthritis, digestive issues like heartburn or diarrhea, cardiovascular disorders, asthma, autoimmune diseases, inflammatory bowel disease, sinus infections, such as bronchitis and sinusitis, surgical trauma and slow healing of skin wounds or burns, poor absorption of drugs, especially antibiotics, and symptoms due to taking medications.

7 Bromelain Benefits and Uses

May Help Prevent DIsease | In studies, bromelain has been found to have natural anti-cancer effects, including promoting apoptotic cell death and preventing tumor growth. It’s been shown in animal studies that it can induce the production of distinct cytokines, that it has antimetastatic efficacy and that it inhibits metastasis by reducing platelet aggregation. Studies have linked bromelain to increased protection against breast and lung cancer, and recently the journal Anticancer Drugs published results from a clinical trial that suggested it affects malignant peritoneal mesothelioma — a rare cancer caused by asbestos exposure. According to the study, it was uncovered that “The addition of bromelain increased the die off of cancer cells (cytotoxicity) significantly… Bromelain has the potential of being developed as a therapeutic agent in treating malignant cancer.”

Helps Treat Digestive Disorders | Why is bromelain good for you if you suffer from indigestion or a gastrointestinal disorder? Because it’s an enzyme that specifically helps with digesting proteins and has been found to help your body absorb nutrients and even medications more efficiently. Studies suggest that it decreases colonic inflammation and reduces secretion of pro-inflammatory cytokines that damage the gut lining. Because it’s very effective at healing tissues within the gastrointestinal tract, bromelain is beneficial for people with any of the following GI problems: Inflammatory bowel disease, ulcerative colitis, dyspepsia or peptic ulcers due to heliobactor pylori infections, constipation, Crohn’s disease, heartburn, and diarrhea.

Supports Faster Recovery from Surgery and Injuries | Bromelain’s anti-inflammatory properties make it a great natural alternative to taking pain-killing medications, such as aspirin. One study that evaluated bromelain’s ability to treat patients who had impacted third molars extracted found that it supported wound healing and helped decrease pain and swelling following the patients’ operations.

Most patients who undergo this surgery experience significant post-operative symptoms, and unfortunately, antibiotics and painkillers are not always effective at preventing infections or other discomfort during the healing process. Of the 80 people who participated in the study, those who were prescribed bromelain reported “significantly lower” post-operation pain, swelling and even redness compared to the control group prescribed a generic painkiller.

Fights Allergies + Asthma | The journal Evidenced-Based Complementary and Alternative Medicinehighlighted the results of a study that investigated how bromelain affected mice suffering from asthma. The study produced some interesting results — for example, that bromelain reduces allergic sensitization and stops development of other inflammatory responses affecting the airways.

These findings suggests that this enzyme helps modulate the entire immune system. It can actually help prevent allergies by addressing the root cause — a hyperactive, oversensitive immune system. It was observed in the study that CD11c (+) dendritic cells and DC44 antigen-presenting cells were kept at bay when supplementing with bromelain, a sign that this enzyme is capable of targeting the underlying cause of asthma and allergies. This is why it helps most people suffering from symptoms like a stuffy/runny nose, itchy eyes, swollen lymph nodes, congestion and trouble breathing.

Helps Treat Sinus Infections| To see whether or not a daily dose of bromelain (300 FIP units, 600-milligram tablets) could help people suffering from chronic sinusitis (inflammation of the sinuses), researchers at the University of Cologne in Germany took 12 patients who had already had sinus surgery and treated them with bromelain for three months. They discovered the following bromelain benefits: Total symptom scores improved, total rhinoscopy scores improved, overall quality of life was enhanced and there were no adverse effects reported. Because surgery can oftentimes be ineffective at treating sinusitis, this research brings a lot of hope to people suffering from chronic sinus problems.

Helps Decrease Joint Pain | Due to its powerful anti-inflammatory and analgesic characteristics, bromelain is fantastic for reducing acute or chronic joint pain. The journal Alternative Therapies in Health and Medicine published a research trial that evaluated 42 osteoarthritis patients with degenerative spine or painful joint conditions. Two 650-milligram capsules of bromelain were given to the patients two to three times each day on an empty stomach (depending on whether they had acute or chronic pain). Researchers discovered that pain decreased up to 60 percent in participants dealing with acute pain and more than 50 percent in those with chronic disorders. The researchers’ conclusion was that “Bromelain has been demonstrated to show anti-inflammatory and analgesic properties and may provide a safer alternative or adjunctive treatment for osteoarthritis.”

May Support Weight Loss |  Does research suggest there’s any link between bromelain and weight loss? Its effects on weight management and fat cells are still under investigation, but there’s reason to believe that it may help with weight loss due to its anti-inflammatory effects, ability to reduce pain, and capability of improving physical abilities and digestion. According to a 2017 article published in PLOS One, “stem bromelain (SBM) is used as an anti-obesity alternative medicine.” Some studies have found that bromelain helps downregulate adipocyte fatty acid-binding protein, fatty acid synthase and lipoprotein lipase. It may also inhibit adipogenesis (cell differentiation that can contribute to formation of fat cells) and reduce triglyceride accumulation.

Bromelain Foods + Sources

Wondering what fruits have bromelain in them, other than pineapple, and are there any other ways to get it other than from eating certain foods? There are three primary ways to incorporate bromelain into your natural health regimen:

Pineapple Core | First, of course, is eating the fiber-rich core of a juicy, ripe pineapple. Bromelain is not found in significant quantities in other fruits, although pineapple is sometimes eaten along with immature, green papaya to increase absorption and provide the beneficial enzyme called papain. Eating pineapple (fresh or frozen) is the very best way to consume natural bromelain. It’s found in all parts of the pineapple but most concentrated in the core. Keep in mind that the riper the fruit is, the softer the core will be. So, make sure you keep your pineapple out on your counter for an extra day or two — this way you’re not gnawing on a tough stem. Note that the flesh of a pineapple is also good for you but doesn’t have the high bromelain content like the core does. The core is where the highest concentration is found.

Juicing Pineapples | Juicing the core of the pineapple or throwing it into a smoothie along with other vegetables like cucumber is an easy way to consume bromelain. Drinking fresh pineapple juice has been suggested to be a powerful remedy against inflammatory diseases. I recommend drinking four ounces a day to help prevent digestive issues and up to eight ounces to treat illnesses like ulcerative colitis, inflammatory bowel disease or constipation.

Bromelain Supplements/Extract | Bromelain supplements are usually found in the form of dried yellow powder, extracted from pineapple juice that is subjected to centrifugation, ultrafiltration and lyophilization. Taking a natural bromelain supplement or proteolytic enzyme supplement with bromelain can be quite effective if you’re treating a specific inflammatory or chronic disease. If you are trying to improve digestion you should take bromelain supplements with meals, but for all other health conditions you should take it on an empty stomach.

Bromelain Supplements and Dosage | How much bromelain should you take each day? The most commonly prescribed dosage ranges between 200–2,000 milligrams daily (usually around 500–800 milligrams per day).  However, for various conditions, many physicians may recommend other dosages. Below are suggested bromelain dosages depending on the condition you’re treating:

To treat arthritis — 400 milligrams taken 1–2 times daily
To help with allergies — 1,000 milligrams daily of bromelain and quercetin
For help preventing cancer — 2,000 milligrams daily, ideally take with other proteolytic enzymes
To improve digestion — 500 milligrams taken 3 times daily with meals; some people choose to mix bromelain powder into water and drink before meals
For help with surgery recovery — 1,000 milligrams 3 times daily taken between meals

Bromelain should be taken on an empty stomach, unless you are taking it to improve digestion. Take it with meals if you’re using it for digestive purposes.

Bromelain is considered a natural supplement and not a medication, therefore it is not regulated by the FDA. However the Dietary Supplement Health and Education Act (DSHEA, 1994) allows the sale of bromelain-containing dietary supplements, especially for the use of treating skin wounds and burns.

In terms of where to buy it, look for bromelain in health food stores or line. Some of the best bromelain supplements combine it with other digestive enzymes, furthering their effects. For example, you’ll find amylase (an enzyme needed to properly digest glucose) in a general digestive enzyme supplement that includes other key digestive enzymes as well. Look for a full-spectrum enzyme blend for general digestive improvement and other benefits.

Bromelain Side Effects and Precautions

Bromelain is usually well-tolerated and unlikely to cause side effects. However, there are some instances when it’s unsafe to take this enzyme. Because it helps prevent blood clots, it’s important to be especially careful when consuming extra pineapple or bromelain supplements if you’re any taking blood-thinning medications. The same applies to surgery: Avoid taking it immediately following surgery unless you speak with your doctor first, as this can increase risk for bleeding.

Side effects that have been associated with this enzyme usually include gastrointestinal symptoms, such as nausea, change in feces and increased gas. Bromelain allergy symptoms are possible and can include itchy mouth or skin, developing a rash, trouble breathing, nasal congestion, and watery eyes.

The Chalkboard Mag and its materials are not intended to treat, diagnose, cure or prevent any disease. 
All material on The Chalkboard Mag is provided for educational purposes only. Always seek the advice of your physician or another qualified healthcare provider for any questions you have regarding a medical condition, and before undertaking any diet, exercise or other health-related programs. 

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